Award details

Improving the duration of immunity for FMD vaccines

Reference	BB/N012682/1
Principal Investigator / Supervisor	Professor Satya Parida
Co-Investigators / Co-Supervisors	Dr Simon Gubbins, Dr Efrain Guzman, Dr Madhuchhanda Mahapatra
Institution	The Pirbright Institute
Department	Livestock Viral Diseases
Funding type	Research
Value (£)	200,103
Status	Completed
Type	Research Grant
Start date	14/05/2016
End date	12/09/2017
Duration	16 months

Abstract

unavailable

Summary

Foot-and-mouth disease (FMD) is a highly contagious viral disease of cattle, pigs, sheep and goats. Currently chemically inactivated, oil adjuvanted FMD vaccines are a critical element in FMD control. Although these vaccines are effective in pigs and ruminants, protective immunity is short-lived (3 months).The need for repeated vaccination significantly constrains vaccine-based control programmes. More appropriate vaccine strains that induce broader protection, together with identification of novel adjuvants that help to stimulate a greater duration of immunity would make a significant contribution to FMD control. In a BBSRC/DFID funded grant we have identified a vaccine strain that provided broader protection and a novel adjuvant that enhanced immunity. The newly formulated vaccine protected all vaccinated animals upon live virus challenge. Therefore we are interested to investigate further whether this new vaccine formulation could achieve longer duration immunity.

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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