Award details

Novel Biocatalysts for Improved Routes to an Active Pharmaceutical Ingredient

Reference	BB/N010736/1
Principal Investigator / Supervisor	Professor Nicholas Turner
Co-Investigators / Co-Supervisors
Institution	The University of Manchester
Department	Chemistry
Funding type	Research
Value (£)	93,738
Status	Completed
Type	Research Grant
Start date	01/02/2016
End date	31/01/2017
Duration	12 months

Abstract

This project will evaluate the feasibility of replacing the current complex chemical syntheses of key intermediates towards Sofosbuvir (Sovaldi), an important drug used in the treatment of Hepatitis C, with biocatalytic steps, offering a shorter route to the product, with enhanced efficiency, economy, and environmental performance. The project will utilise the expertise of the University of Manchester in enzyme discovery and engineering to provide the new catalysts, and the manufacturing expertise of Dr. Reddy's to assess the feasibility of using these catalysts on an industrial scale.

Summary

The use of enzymes to catalyse reactions is a well established technique used in modern organic chemistry as the use of biological catalysts can install unique and exquisite stereochemistry and regiochemistry into a synthetic route. This project will explore the development of two enzymes that catalyse important bond forming reactions in the synthesis of an Active Pharmaceutical Ingredient and their suitability for use as industrial biocatalysts.

Impact Summary

As described in the proposal submitted to IUK

Committee	Not funded via Committee
Research Topics	Industrial Biotechnology, Pharmaceuticals
Research Priority	X – Research Priority information not available
Research Initiative	Industrial Biotechnology Catalyst (IBCAT) [2014-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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