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Clinical applications of recombinant CSF1-Fc produced in the eggs of transgenic hens in veterinary and human medicine

Reference	BB/M021920/1
Principal Investigator / Supervisor	Professor Helen Sang
Co-Investigators / Co-Supervisors	Dr Andrew Gill, Professor David Hume
Institution	University of Edinburgh
Department	The Roslin Institute
Funding type	Research
Value (£)	554,485
Status	Completed
Type	Research Grant
Start date	11/05/2015
End date	31/10/2017
Duration	30 months

Abstract

unavailable

Summary

Biologics are pharmaceutical proteins very effective at treating a number of previously intractable medical conditions. They are an increasing proportion of the human drugs market, but widespread use in veterinary settings has been prevented by high production cost. Replacing the expensive mammalian cell culture systems with transgenic chickens has significant potential to reduce this cost. With our system, hens can produce protein of consistent quantity and activity over their entire laying lives, and purification is performed using standard techniques. Here we propose to take forward our recent success producing active pig CSF1-Fc in transgenic hens' eggs by purifying large quantities and testing in potential applications. We will scale up purification, perform full quality control, test in pig models of human disease, and provide material to other experts for evaluation. We will also produce a new transgenic line expressing dog CSF1-Fc for future studies in veterinary medicine.

Committee	Not funded via Committee
Research Topics	Animal Health, Industrial Biotechnology, Technology and Methods Development
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund Super (SuperFOF) [2012-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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