Award details

Small molecule inhibitors for bovine respiratory syncytial virus

Reference	BB/L024438/1
Principal Investigator / Supervisor	Professor Andrew Easton
Co-Investigators / Co-Supervisors	Dr Andrew Marsh
Institution	University of Warwick
Department	School of Life Sciences
Funding type	Research
Value (£)	194,725
Status	Completed
Type	Research Grant
Start date	01/12/2014
End date	31/08/2016
Duration	21 months

Abstract

unavailable

Summary

Infection of cattle with bovine respiratory syncytial virus is a worldwide problem and results in losses of more than £150 million for the UK farming industry alone. We have shown that BRSV and related viruses express an essential protein, M2-2, by using a novel mechanism that relies on the action of a protein, DDX3 that is present in the cells that the viruses infect. If the virus M2-2 protein is not made in sufficient amounts the virus cannot grow effectively. We have identified a number of inhibitors that interfere with the action of the DDX3 protein and as a result prevent production of the M2-2 protein. This treatment prevents the growth of BRSV and its related viruses. We intend to develop these inhibitors as potential drugs to combat the virus.

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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