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ProteoFormer - a software toolkit for top-down proteomics

ReferenceBB/L018454/2
Principal Investigator / Supervisor Professor Andrew Dowsey
Co-Investigators /
Co-Supervisors
Institution University of Liverpool
DepartmentElectrical Engineering and Electronics
Funding typeResearch
Value (£) 21,768
StatusCompleted
TypeResearch Grant
Start date 01/02/2015
End date 31/01/2016
Duration12 months

Abstract

unavailable

Summary

unavailable

Impact Summary

Our developments will have impacts through the following routes: - The development of seaMass-TD and Proteoformer will make it more straightforward for top-down analysis to be performed on a much wider range of instruments, producing high-quality and reliable results. This will open up this important technology for studying proteins in their native state in the cell, for basic and applied research across numerous domains. - Our software has the potential to increase sales of mass spectrometers, capable of performing top-down analysis. In particular, locally we are working with Waters to develop software compatible with their data, since current software has typically been designed for mass spectrometers produced by Thermo. - We will explore routes for commercialisation of Proteoformer and seaMass-TD, as discussed in the Pathways to Impact document. - We will work with international consortia aimed with data sharing and standardisation in proteomics - the Proteomics Standards Initiative (PSI), ProteomeXchange and EBI's PRIDE database to ensure that current standards can appropriately handle top-down data, and researchers can submit data to the leading public repositories for community re-analysis.
Committee Not funded via Committee
Research TopicsTechnology and Methods Development
Research PriorityX – Research Priority information not available
Research Initiative Tools and Resources Development Fund (TRDF) [2006-2015]
Funding SchemeX – not Funded via a specific Funding Scheme
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