Award details

Regulating Appetite by Targeting Nutrient Delivery in the Gut

Reference	BB/L004259/1
Principal Investigator / Supervisor	Professor Gary Frost
Co-Investigators / Co-Supervisors	Professor Stephen Bloom, Professor Waljit Dhillo, Dr Douglas Morrison, Professor Kevin Murphy, Professor Tom Preston, Professor C Tedford
Institution	Imperial College London
Department	Dept of Medicine
Funding type	Research
Value (£)	805,178
Status	Completed
Type	Research Grant
Start date	01/02/2014
End date	31/01/2016
Duration	24 months

Abstract

unavailable

Summary

The prevalence of obesity has risen rapidly and robustly in the past fifty years due to the easy availability of energy dense foods in a sedentary environment. Targeting the body's appetite-regulating systems to control calorie intake is a novel and consumer friendly approach to weight management. A promising approach is to deliver specific nutrients to the specific site in the gastrointestinal tract where they trigger nutrient sensing circuits which in turn signal to the brain to reduce food intake. We have shown that this gut-brain axis can be manipulated to reduce subsequent food intake. This project aims to demonstrate "molecule to product" capability and examine the potential market for health claims from this and prior work. The evidence generated in the current BBSRC study will support a health claim, and the potential to market satiating products with scientifically proven effects represents a significant commercial opportunity which we wish to develop with Follow-on-Funding.

Committee	Not funded via Committee
Research Topics	Diet and Health
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund Super (SuperFOF) [2012-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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