Award details

A novel polymer system as a bone void filler in reconstructive revision arthroplasty.

Reference	BB/K020331/1
Principal Investigator / Supervisor	Professor Julie Gough
Co-Investigators / Co-Supervisors	Professor Peter Budd, Professor Sandra Downes, Professor Judith Hoyland, Professor David Christopher Watts
Institution	The University of Manchester
Department	Materials
Funding type	Research
Value (£)	499,468
Status	Completed
Type	Research Grant
Start date	01/07/2013
End date	08/09/2015
Duration	26 months

Abstract

unavailable

Summary

The aim of this project is to develop a simple to use, pliable, bioactive composite for reconstruction of bone in revision joint replacement. The novel, synthetic, polymer system will have a putty-like consistency, which is malleable by the surgeon but will set to solid consistency, when placed in contact bone during Orthopaedic surgery. BBSRC Super FoF is required to develop bone void filler, to a detailed and challenging specification. We will optimise the chemistry and formulation of the composite and detailed biomechanical and in vitro biological studies will be made. We intend to prove efficacy and elucidate the biological mechanisms of the osteoinductive properties. Two pre-clinical trials are planned. The research work has the support of S+N, with a commitment to take the project (if successful) into the development of a product for use in the clinic. The benefits to patients will be; improved surgical methods to fill bone voids in revision joint replacements (hips and knees).

Committee	Not funded via Committee
Research Topics	Regenerative Biology
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund Super (SuperFOF) [2012-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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