Award details

Manufacturing of iPS cell derived neurons from patients with familial Alzhiemer's disease for drug discovery and stratified medicine applications

Reference	BB/K020277/1
Principal Investigator / Supervisor	Dr Christopher Ward
Co-Investigators / Co-Supervisors	Dr Lisa Mohamet
Institution	The University of Manchester
Department	Dentistry
Funding type	Research
Value (£)	170,769
Status	Completed
Type	Research Grant
Start date	01/05/2013
End date	31/03/2015
Duration	23 months

Abstract

unavailable

Summary

Progress in understanding many diseases has been hindered by a lack of suitable in vitro models, particularly for diseases in which affected cell types are difficult to access or obtain. Induced pluripotent stem cells (iPSCs) are an ideal alternative source as they can be derived from patients' skin cells and have the potential to form any cell type in the body. However, current technologies are hindered by the inability to reliably produce mature cell types. We have developed a method that enables iPSCs to be reliably differentiated at low cost and high purity into neurons. This offers the ability to utilise these cells for understanding Alzheimer's disease (AD) in the petri dish and developing new treatments and diagnostics for such patients. Ultimately, we aim to produce a technology capable of diagnosing AD and informing treatment options for patients as well as providing industry with the ability to screen and develop novel drugs for this incurable disease.

Committee	Not funded via Committee
Research Topics	Neuroscience and Behaviour, Pharmaceuticals, Stem Cells
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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