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Adaptation of a high resolution, high throughput assay of immunoglobulin repertoires for commercial and clinical applications

Reference	BB/K010867/1
Principal Investigator / Supervisor	Dr Anne Corcoran
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Chromatin and Gene Expression
Funding type	Research
Value (£)	138,187
Status	Completed
Type	Research Grant
Start date	26/09/2012
End date	04/12/2013
Duration	14 months

Abstract

unavailable

Summary

Our immune system makes millions of different antibodies to fight infection by cutting and pasting together large sets of antibody genes in many different combinations. It is currently not possible to measure them all and it would be extremely useful to be able to do so. First, immunodeficient patients who can't make antibodies could be diagnosed and treated quicker and more accurately. Second many companies are making mouse models that generate human antibodies as powerful therapies against specific infections. They need to know which antibodies are amplified in response to a particular infection. We have developed VDJ-seq, an assay that can identify several hundred thousand different mouse antibody sequences in a sample. We will adapt VDJ-seq to analyse immunodeficient human patient samples and mouse models producing human antibodies in a rapid, high-throughput, cost-effective way that aims to improve patient treatment and accelerate commercial discovery of therapeutic antibodies.

Committee	Not funded via Committee
Research Topics	Immunology, Pharmaceuticals
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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