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Sub-Cellular OCT Imaging

Reference	BB/J021571/1
Principal Investigator / Supervisor	Professor Richard Hogg
Co-Investigators / Co-Supervisors	Dr david childs, Professor Stephen Matcher
Institution	University of Sheffield
Department	Electronic and Electrical Engineering
Funding type	Research
Value (£)	125,816
Status	Completed
Type	Research Grant
Start date	01/06/2012
End date	31/05/2013
Duration	12 months

Abstract

unavailable

Summary

Optical coherence tomography (OCT) allows the 3D imaging of skin tissue on a depth scale of ~1-2mm with resolution ~10um. It has been described as an optical analog of ultrasound imaging and offers significantly better resolution than MRI and ultrasound. It has already gained clinical acceptance in ophthalmology and is emerging into other fields such as oncology, monitoring wound healing, cardiology, and guided surgery. The advantages of OCT include:- Video rate images of sub-surface morphology at resolutions ~100 better than ultrasound and voxel rates ~1000 higher than microscopy. Label-free imaging of the sample (in vivo or in vitro). Non-ionizing radiation. Non-contact Endoscopic OCT is ideal for imaging 1~2mm below the surface in biological tissue. Our project is concerned with the development of a prototype swept laser source with 200 - 300 nm sweep range providing sub cellular resolution. We will develop the laser system and trial it in an OCT imagining system.

Committee	Not funded via Committee
Research Topics	Technology and Methods Development
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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