Award details

Realising the potential of a genetically engineered and uniquely cross protective vaccine for Bluetongue disease

Reference	BB/J021342/1
Principal Investigator / Supervisor	Professor Polly Roy
Co-Investigators / Co-Supervisors
Institution	London Sch of Hygiene and Trop Medicine
Department	Infectious and Tropical Diseases
Funding type	Research
Value (£)	137,479
Status	Completed
Type	Research Grant
Start date	10/09/2012
End date	03/02/2014
Duration	17 months

Abstract

unavailable

Summary

Bluetongue disease is a debilitating and, in severe cases, lethal, animal disease that is a major economic threat to livestock and agriculture. Current vaccines available for Bluetongue are not considered to be safe enough for widespread use. Our laboratory has developed a replication defective (DISC) virus that can be used safely as an alternative BTV vaccine with none of the existing issues. In order to commercialize this vaccine a number of optimizations are necessary. In particular, the stability of the specialized cells which support the growth of the vaccine virus will be optimized. Moreover, to ensure that the DISC virus does not change with time, we will monitor for potential changes in the growth of the virus, expression of virus proteins and genome. The optimal storage conditions for vaccine and number of dose required will be determined in sheep to ensure that protection afforded is maximized.

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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