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Exploiting plant synthetic biology for the production of glycoproteins in plant chloroplasts.

Reference	BB/J019070/1
Principal Investigator / Supervisor	Professor Ian Roberts
Co-Investigators / Co-Supervisors	Professor Peter Andrew, Dr Anil Day
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	119,827
Status	Completed
Type	Research Grant
Start date	01/03/2012
End date	28/02/2013
Duration	12 months

Abstract

unavailable

Summary

Vaccination has played a major role in reducing the health burden of infectious diseases. It offers an effective route by which serious infections, usually of the young, can be effectively eradicated. The most effective vaccines to prevent infections are conjugate vaccines. These are made by chemically joining a polysaccharide from the pathogen to a carrier protein. A major drawback of the current methodology for the generation of conjugate vaccine is the cost of production and the hazards associated with growing large amounts of pathogen. This proposed work will address these problems by synthesising conjugate vaccines directly in plant chloroplasts. Chloroplasts are plant organelles that carry out photosynthesis. Localising conjugate vaccine production inside the chloroplast will facilitate purification and permit large amounts of material to be produced. In the future this approach may allow the purification and manufacture of vaccines from edible plants for oral immunisation.

Committee	Not funded via Committee
Research Topics	Industrial Biotechnology, Pharmaceuticals, Plant Science
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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