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Application of the SMALP system to generate antibodies for intact transmembrane proteins

Reference	BB/J010812/1
Principal Investigator / Supervisor	Professor Michael Overduin
Co-Investigators / Co-Supervisors	Dr Fedor Berditchevski, Professor Timothy Dafforn, Professor Mark Wheatley
Institution	University of Birmingham
Department	Cancer Sciences
Funding type	Research
Value (£)	151,570
Status	Completed
Type	Research Grant
Start date	01/04/2013
End date	30/09/2014
Duration	18 months

Abstract

unavailable

Summary

The analysis and exploitation of transmembrane proteins has recently become one of the most exciting areas of drug discovery and biological research. About a third of all proteins are found in membranes, their mechanisms are particularly difficult to study as they are often present only in small amounts and are difficult to handle. These proteins are stabilized by their interactions with native lipids but current methods to study them depend on detergents which strip these lipids away. We have developed a novel bionanoparticle to prepare functionally intact proteins directly from native membrane maintaining the local lipid environment and propose to develop antibodies to these targets for therapeutic and research purposes. This new generation of antibodies will allow specific recognition of native protein states with unprecedented accuracy, and will enable development of new diagnostic tests and biotherapeutic agents for treatment of cancer and many infectious and genetic diseases.

Committee	Not funded via Committee
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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