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A New Approach to the Chemical Modification of Antibodies via Maleimide Bridging of Disulfides

Reference	BB/J010448/1
Principal Investigator / Supervisor	Professor James Baker
Co-Investigators / Co-Supervisors	Professor Stephen Caddick
Institution	University College London
Department	Chemistry
Funding type	Research
Value (£)	140,099
Status	Completed
Type	Research Grant
Start date	01/03/2012
End date	28/02/2013
Duration	12 months

Abstract

unavailable

Summary

We are entering extremely exciting times in the development of the next generation of therapeutics, as scientists have turned their attention to the manipulation of part of nature's own defense mechanism; antibodies. Antibodies can now be designed in the lab to target a variety of diseases, including cancer and infectious diseases. They represent the fastest growing class of therapeutics, with a market value estimated to be around $50 billion. Currently however, a limiting factor in the area is the lack of reliable chemical methods that will allow the modification and optimisation of the properties of antibodies. We are proposing here to exemplify a new class of chemical reagents that will allow the highly effective modification of antibodies for the first time. This exemplification will enable us to establish partnerships with pharmaceutical and biotechnology companies to facilitate the optimisation of future antibody-based therapeutics.

Committee	Not funded via Committee
Research Topics	Immunology, Pharmaceuticals
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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