Award details

Standards for the Design and Engineering of Modular Biological Devices

Reference	BB/F018746/1
Principal Investigator / Supervisor	Professor Alistair Elfick
Co-Investigators / Co-Supervisors	Professor James Haseloff
Institution	University of Edinburgh
Department	Sch of Engineering
Funding type	Research
Value (£)	188,181
Status	Completed
Type	Research Grant
Start date	01/06/2008
End date	30/11/2011
Duration	42 months

Abstract

Synthetic biology is positioned to make a substantial contribution to global society through its economic and environmental impact. The early adoption of engineering practises such as abstraction and standardisation has been highly enabling, but further development of these concepts is urgently required. This Network will contribute to discussion, refinement and dissemination of the global standard in synthetic biology, the BioBrick. Two important aspects of standardisation are to be considered; (i.) improving standards for the description of BioBrick properties and BioBrick utilisation and (ii.) developing protocols for the development of bioinformatic models based on the BioBrick concept. We will address questions such as: Should part characterisation be performed at the single cell level or be population based? and, Can modelling modules be designed to be plug-and-play in the way that modular biological parts are? The Network will include social scientists and lawyers so we can consider the IP, regulatory and societal aspects of this open-source approach to standardisation in synthetic biology. Network outputs will be disseminated formally via an interface with the annual BioSysBio conference and a partnership with the IET Synthetic Biology journal, of which the applicants are editors, and informally through mechanisms such as web-based discussion forums and mailing lists. The Network will also produce validated lab protocols, reagents for 'standard operating conditions' and so on. For the continued advancement of the field, the refinement of the modular parts standards and the provision of additional standards relating to wet-lab protocols, parts characterisation and modelling are essential. Funding of larger-scale synthetic biology research in the next few years may well be contingent on the deliberations and outputs of this research network in terms of developing infrastructure and thinking for future productive research. Co-funding provided by EPSRC, ESRC and AHRC under the Networks in Synthetic Biology initiative.

Summary

Synthetic biology is a new discipline in which scientists are applying techniques more commonly found in engineering to the design and construction of biological devices which have programmed function. The approach uses small parts known as BioBricks which can be quickly and easily joined together to give a desired function. This parts based approach was inspired by standardisation, something commonplace in engineering and everyone's daily lives. Standards can be found everywhere from the supermarket, a kilo of apples weighs the same anywhere, to the building site, a door made in Wales will fit a Scottish doorframe in an English wall! There have been a number of synthetic biological devices made, most of which have shown unusual and interesting behaviour such as pulsing fluorescence or sensing the edge of a shadow for example. We are on the cusp of a revolution in which many valuable products, from drugs to fuel, will be synthesised within biological organisms which have been reprogrammed to achieve this. To help enable this technology there has been the realisation that the standards are in urgent need of refinement. There are many unanswered questions regarding the standards which need to be addressed. For example, how can we measure a part's performance in such a way that everyone can know how the part will function in their particular device? Another example might be how do can we build a computer simulation to predict device performance from these descriptions of parts? We have assembled a group of Britain's leading synthetic biologists who will meet regularly to discuss, define and develop robust standards for synthetic biology. This group will meet in the UK and in the US with invited experts in the field. Importantly, we will consider other aspects of parts based synthetic biology such as who owns intellectual property rights to parts and how the field should be regulated. To assist us in this we have been joined by leading social scientists and lawyers who have established expertise in biotechnology and genomics. The results of the discussions will help to communicate the agreed standards throughout the synthetic biology community. We will also create resources such as validated protocols for synthetic biologists to use. These activities have significant potential to energise the synthetic biology community both at home and abroad and help to put the UK at the front of synthetic biology in Europe.

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	Synthetic Biology
Research Priority	X – Research Priority information not available
Research Initiative	Networks in Synthetic Biology (NSB) [2007]
Funding Scheme	X – not Funded via a specific Funding Scheme

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