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Commercialisation potential of a decellularised porcine bladder matrix.
Reference
BB/E527220/1
Principal Investigator / Supervisor
Professor Jennifer Southgate
Co-Investigators /
Co-Supervisors
Institution
University of York
Department
Biology
Funding type
Research
Value (£)
89,833
Status
Completed
Type
Research Grant
Start date
01/08/2007
End date
31/07/2008
Duration
12 months
Abstract
unavailable
Summary
We have developed a novel procedure to decellularise full-thickness porcine bladder tissue by utilising the bladder's unique capacity for expansion; a patent is in application. The resultant biometerial is highly stable in its non-cross-linked form, non-cytotoxic in cell culture and retains the strength and compliant properties of the native urinary bladder. Prior to commercialisation, further pre-clinical evaluation of the decellularised porcine bladder tissue is required in order to identify benchmark biomechanical properties, investigate the immunological status and determine whether the biomaterial is able to support both in vitro and in vivo recellularisation. This information is necessary in order to identify specific clinical uses and target appropriate commercialisation sectors.
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
Industrial Biotechnology, Regenerative Biology
Research Priority
X – Research Priority information not available
Research Initiative
Follow-On Fund (FOF) [2004-2015]
Funding Scheme
X – not Funded via a specific Funding Scheme
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