Award details

xBASE: a bioinformatics resource for the AgriFood bacteriology community

Reference	BB/E011179/1
Principal Investigator / Supervisor	Professor Mark Pallen
Co-Investigators / Co-Supervisors	Professor Dov Stekel
Institution	University of Birmingham
Department	Immunity and Infection - Infection
Funding type	Research
Value (£)	777,649
Status	Completed
Type	Research Grant
Start date	01/02/2007
End date	31/01/2012
Duration	60 months

Abstract

Bacteria play important roles at every stage in the human food chain, from improving the productivity of the soil to infecting the human consumer. The era of genomics and systems biology brings the promise of unparalleled progress in the study of bacteria of agricultural importance. However, if the average bacteriologist is unable to exploit the new flood of new sequence and interaction data, the whole genomics enterprise risks becoming expensive molecular stamp-collecting exercise. In recent years, we have met this challenge by providing bacteriologists with user-friendly tools for visualising, analysing and exploiting genome sequence data from bacteria that affect the human food chain. Our most recent effort is coliBASE, a web site and database dedicated to the comparative genomics of E. coli and related bacteria of relevance in the AgriFood context . As evidence of its success, this site is receiving >1000 visitors a month. In this proposal, we aim to sustain these facilities into the second decade of the twenty-first century by the development of xBASE, a series of taxon-specific databases, in which we add breadth (by covering a wider range of organisms) and add depth (by adding additional analytical and visualization tools, including new tools to cope with data from bacterial Systems Biology and meta-genomics projects) to our current repertoire. xBASE will be implemented through the use of a MySQL database running on a Linux cluster, augmented with visualization, graphing and other software

Summary

Bacteria play important roles at every stage in the human food chain, from improving the productivity of the soil to infecting the human consumer. The advent of genome sequencing, functional genomics and systems biology brings the promise of unparalleled progress in the bacteriology of the human food chain. However, bacteriologists are drowning in in a sea of data. Hundreds of bacterial genome projects have been completed or are underway. On top of this, we are now threatened with a novel deluge of data from systems biology studies . Unless the average bacteriologist is able to exploit the new flood of genomics data, the whole genomics enterprise risks becoming an expensive molecular stamp-collecting exercise. In recent years, we have met this challenge by providing bacteriologists with a set of user-friendly tools for visualising, analysing and exploiting genome sequence data from bacteria of importance to the human food chain. Our most recent effort is coliBASE, a web site and database dedicated to the comparative genomics of E. coli and related bacteria of relevance in the AgriFood context. As evidence of its success, this site is receiving >1000 visitors a month. In this proposal, we aim to take these facilities into the second decade of the twenty-first century by the development of xBASE, a series of taxon-specific databases, in which we add breadth (by covering a wider range of organisms) and add depth (by adding additional analytical and visualization tools, including new tools to cope with data from bacterial Systems Biology and meta-genomics projects) to our current repertoire.

Committee	Closed Committee - Agri-food (AF)
Research Topics	Microbial Food Safety, Microbiology, Technology and Methods Development
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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