Award details

Development of a kit form of 'MAX' randomisation

Reference	BB/D525756/1
Principal Investigator / Supervisor	Professor Anna Hine
Co-Investigators / Co-Supervisors
Institution	Aston University
Department	Sch of Life and Health Sciences
Funding type	Research
Value (£)	58,338
Status	Completed
Type	Research Grant
Start date	10/01/2006
End date	09/01/2007
Duration	12 months

Abstract

As part of BBSRC Grant B14245 (end date 9/1/05), a new gene randomisation process named MAX randomisation was developed. Gene randomisation is a high-throughput mutagenesis technique which is used in commercial protein engineering, when good information concerning the structure of the target protein is available. However, gene randomisation has drawbacks (associated with the degeneracy of the genetic code) including high wastage ratios and unequal protein concentrations in resulting protein libraries, that are likely to compromise protein screening. MAX randomisation cures both of these issues and the current application seeks to develop a kit form of the procedure for subsequent marketing by a University spin-off company, ProtaMAX Ltd. The applicant is currently on a secondment to Aston University's Business Partnership Unit to see through the commercialisation process and aid to colleagues in their own University commercialisation ventures. AVH's career development/ProtaMAX are to be featured in the BBSRC's Annual Report & Accounts 04/05.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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