Award details

Evaluation of optimised heparins as novel therapeutics for Alzheimers Disease

Reference	BB/D525713/1
Principal Investigator / Supervisor	Professor Jeremy Turnbull
Co-Investigators / Co-Supervisors
Institution	University of Liverpool
Department	Sch of Biological Sciences
Funding type	Research
Value (£)	59,839
Status	Completed
Type	Research Grant
Start date	08/05/2006
End date	07/08/2007
Duration	15 months

Abstract

The key step in the generation of toxic Abeta peptides that cause Alzheimer's disease (AD) is the action of an enzyme known as BACE1. We have recently discovered that a naturally occurring complex sugar called heparan sulphate (HS) is a regulator of BACE1 activity. The anti-coagulant drug heparin is a member of the HS family of molecules and we have generated a semi-synthetic modified heparin as a lead compound which is a powerful BACE1 inhibitor, has very low anticoagulant activity, and is not toxic in mice. Optimised heparins thus have potential as a new class of anti-AD drugs. In this proposal we will test a novel modified heparin in a validated mouse model of AD, and make initial assessments of the bioavailability of the compound and its ability to cross the blood/brain barrier. An assessment of the potential market for a novel heparin-based Alzheimer's drug will also be made. The overall goal of this project will be to establish proof-of-concept in an animal model of the use of an optimised heparin as a novel treatment for Alzheimer's Disease. This will enhance the opportunities for commercial exploitation through either a licening deal or development of a spin out company.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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