Award details

Knowledge-based improvement of antibiotic production and discovery:increasing yields from indistrial strains and identifying novel therapeutics targets

Reference	BB/D525705/1
Principal Investigator / Supervisor	Professor Mervyn Bibb
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre
Funding type	Research
Value (£)	58,919
Status	Completed
Type	Research Grant
Start date	01/01/2006
End date	31/12/2006
Duration	12 months

Abstract

Streptomycetes and their relatives are important sources of pharmaceutically active compounds, supplying many currently used antibiotics. Our laboratory has pioneered the development of genetic and molecular techniques to dissect the complex regulatory mechanisms that control the onset of secondary metabolism in streptomycetes. This knowledge can now be applied to engineer strains with quantitative improvements in antibiotic production. To commercialise this technology it is necessary to perform proof-of-principle experiments in industrially relevant strains. This project will use a novel mass spec-based technology to identify regulatory proteins required for the production of the peptide antibiotic cinnamycin (in partnership with Novacta Biosystems Ltd), the aminoglycoside kanamycin, and the cyclic lipopeptide daptomycin (marketed as CubicinTM). The technology will also be used to identify regulators of virulence in the human pathogen Staphylococcus aureus as a demonstration of our ability to define novel therapeutic targets that will be valuable in the effort to detect new classes of antibiotics.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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