Award details

High throughput analysis of gene expression using transcriptomics

Reference	BB/D524667/1
Principal Investigator / Supervisor	Dr Christopher West
Co-Investigators / Co-Supervisors	Professor Peter Urwin
Institution	University of Leeds
Department	Ctr for Plant Sciences
Funding type	Research
Value (£)	64,906
Status	Completed
Type	Research Grant
Start date	01/01/2006
End date	30/09/2006
Duration	9 months

Abstract

The genomics equipment will provide essential research infrastructure within the Faculty of Biological Sciences and will support research group projects across a range of disciplines from Plant Science to Pathology. The requested equipment includes: the high resolution, multi-format Agilent microarray scanner, a GeneSpring workstation for microarray data analysis and a NanoDrop ND-1000 UV-Vis spectrophotometer for rapid, accurate analyses of extremely small biological samples. This equipment will be integrated into the faculty¿s genomics facility and will streamline and standardise microarray hybridisation protocols. Microarray-based global expression analysis will enable the development of greater integrative or holistic understanding of biological processes. Transcriptomics technologies also form an important part of the BBSRC ten year plan and are a central aspect of the NERC Post Genomics and Proteomics initiative and Environmental Genomics research programme. These initiatives highlight the power of microarrays to determine the role of gene regulation in cellular differentiation, disease and responses to the environment. Statistical analysis of global gene expression allows the identification of novel genes with potential roles in specific cellular pathways. These methodologies represent invaluable tools in the characterisation of the large numbers of genes of unknown function identified in the sequenced genomics of model organisms.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Research Equipment Initiative 2005 (RE5) [2005]
Funding Scheme	X – not Funded via a specific Funding Scheme

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