Award details

Modelling Inference and Analysis for Biological Systems up to the Cellular Level

Reference	BB/D524659/1
Principal Investigator / Supervisor	Professor David Gilbert
Co-Investigators / Co-Supervisors	Professor Rainer Breitling, Professor Muffy Calder, Professor Mark Girolami, Dr Pawel Herzyk, Dr David Leader, Professor Richard Sinnott
Institution	University of Glasgow
Department	School of Computing Science
Funding type	Research
Value (£)	126,426
Status	Completed
Type	Research Grant
Start date	01/03/2006
End date	31/03/2007
Duration	13 months

Abstract

To facilitate the activities in the Bioinformatics Research Centre (BRC) in the area of modelling biological systems. In order to carry out these research activities, we urgently need to upgrade and improve our computing facilities, which are now ageing since their purchase in 2002 and will be nearly 4 years only by January 2006. We request support for central, shared computing facilities which would not be eligible on standard grant applications. Uniquely, the Centre is part of the Department of Computing Science but is physically located in the Faculty of Biomedical and Life Sciences, and thus is ideally placed to carry out truly interdisciplinary research at the intersection between the computational and life sciences. This is reflected both in the inter-faculty nature of the research team, numbering over 20 researchers from both computing Science and the Institute of Biomedical and Life Sciences as well as the projects which we carry out. An exemplar is the large Beacon project on modelling and analysing signalling pathways ¿ the team involves wet-lab scientists who produce real data for the modellers. We now with to strengthen our focus on the systems biology oriented activities, and to bring this together with our activities in statistical machine learning. The development of computational models which are faithful representations of the system under study will be employed as simulators to verify and test inferential methods we intend to develop for the reverse-engineering of systems such as transcriptional networks. In doing so, we wish to further integrate our eScience research with this core, and to provide cross funding for Structural Bioinformatics which is an established strength in the Centre. We wish to continue and strengthen our activities of modelling at the component level of biological systems, since the processes described and predicted by system-level models take place at the molecular level. The users of the research supported by the equipmentwill be life science researchers. Advances in technology and laboratory techniques mean that they have access to data which is sufficient in many cases to attempt some modelling of the biological systems of interest. The aim of the Bioinformatics Research Centre aims to carry out research in collaboration with life scientists in order not only to construct models but also analyse them in-silico.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Research Equipment Initiative 2005 (RE5) [2005]
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search