Award details

Computing Equipment for Bioinformatics

Reference	BB/D524508/1
Principal Investigator / Supervisor	Professor Michael Sternberg
Co-Investigators / Co-Supervisors	Dr Sarah Butcher, Professor Michael Stumpf
Institution	Imperial College London
Department	Biological Sciences
Funding type	Research
Value (£)	150,193
Status	Completed
Type	Research Grant
Start date	01/12/2005
End date	31/08/2006
Duration	9 months

Abstract

The proposed research builds on existing strengths in structural bioinformatics, theoretical genomics, computational statistics and provision of bioinformatics services and infrastructure for the Imperial College research community. Our research is an integral part of ongoing university activities and strong links will exist to the new BBSRC Centre for Integrated Systems biology and the Imperial College Institute for Mathematical Sciences. The equipment requested for this proposal will be essential for the three applicants¿ research and infrastructure requirements over the next 3 years. In particular we aim to employ the equipment in ¿ prediction of protein structures using an array of different techniques, including fold-recognition, fragment-based and hybrid approaches. Analysis of protein-protein docking. Functional prediction of proteins based on sequence similarity and gene ontology information. Proteome annotation. Statistical and comparative analysis of biological network data. Evolutionary and comparative genomics of gene regulation. Analysis of complex population genetics data. Modelling of biological processes at different levels (molecules, cells, tissues, organisms, populations). The groups of Professor Sternberg and Dr Stumpf are heavily involved in the development and application of algorithms in these areas. The need to incorporate a range of diverse and complex data sets in order to make predictions or inferences in bioinformatics and the importance of thoroughly evaluating algorithms before applying them to biological problems has lead to a considerable increase in the computational needs of both groups. The bioinformatics support service (BSS), headed by Dr Sarah Butcher, provides a pivotal element to bioinformatics research at Imperial College London. The BSS maintains dedicated bioinformatics hardware and software, as well as providing advice for its users which come from all faculties (including currently 49 BBSRC grant holders). Without locallyavailable database an increasing amount of work would become impossible and the system requested for BSS is targeted specifically at providing a highly flexible, powerful and extendable architecture for present and future needs of the bioinformatics (user) community, including a large number of BBSRC stakeholders.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Research Equipment Initiative 2005 (RE5) [2005]
Funding Scheme	X – not Funded via a specific Funding Scheme

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