Award details

Faraday earmarked proposal: Toll-like receptors and dendritic cell genetic heterogeneity

Reference	BB/D524059/1
Principal Investigator / Supervisor	Professor Tracey Coffey
Co-Investigators / Co-Supervisors	Professor Jayne Hope, Professor Dirk Werling
Institution	The Pirbright Institute
Department	Div of Immunology Compton
Funding type	Research
Value (£)	111,876
Status	Completed
Type	Research Grant
Start date	10/04/2006
End date	09/01/2010
Duration	45 months

Abstract

Improvement in the efficacy of vaccines and the identification of genetic traits affecting disease resistance will have a large impact on disease control in livestock. Many current vaccines are live vaccines with limited long term protection. Variable responsiveness to vaccines has been observed across populations and includes non-responsiveness as well as pathogenic responses. Disease resistance traits are also highly variable both between and within breeds. Variability in both vaccine responsiveness and disease resistance traits can have moderate to high heritability and the genes underlying these traits are likely to overlap, and involve both Major Histocompatibility Complex (MHC) and non-MHC genes. Major goals for the UK pharmaceutical and breeding industries would be to create uniformly efficacious non-live subunit vaccines for livestock and identify suitable markers for breeding for disease resistance and vaccine responsiveness. Our contention is that there will be genes underlying these traits that are expressed in the innate immune system. Specifically, this proposal will concentrate on the expression, function and polymorphism of pathogen-recognition receptors (PRR), specifically the toll-like receptors (TLR) found on authentic dendritic cells (DC) derived from cattle and sheep afferent lymph. These cells are a major component of the innate immune system and form an instructive link between the innate and acquired (adaptive, antigen-specific lymphocyte-mediated) immune systems.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Immunology
Research Priority	X – Research Priority information not available
Research Initiative	Faraday: Genesis (FGEN) [2004-2005]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BB/D524040/1 Faraday earmarked proposal: Toll-like receptors and dendritic cell genetic heterogeneity

BB/D524040/2 Faraday earmarked proposal: Toll-like receptors and dendritic cell genetic heterogeneity

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