Award details

The 'Magic Tag' Kit: A tool for simple rapid immobilisation of bioactive molecules for chemical genomics applications.

Reference	BB/C524338/1
Principal Investigator / Supervisor	Professor Paul Taylor
Co-Investigators / Co-Supervisors	Dr Andrew Clark, Dr Andrew Marsh
Institution	University of Warwick
Department	Chemistry
Funding type	Research
Value (£)	51,820
Status	Completed
Type	Research Grant
Start date	01/07/2005
End date	30/04/2006
Duration	10 months

Abstract

Discovering and understanding interactions between small bioactive molecules and protein receptors is fundamental to the development of novel pharmaceuticals and agrochemical agents. There are many bioactive molecules for which the target receptor is unknown. Our product is a simple and highly efficient Magic Tag Kit that allows immobilisation of a small bioactive molecule in a format that maximises the chances of identifying the target receptor for the bioactive molecule in a library representing the proteome of an organism of interest. The Magic Tag Kit will consist of a 96 well plate, each well containing a solid support, chemically derivatised with a species that will generate a reactive intermediate capable of covalently bonding a bioactive molecule when activated. The tagged bioactive molecule will be used to isolate and identify receptors for the bioactive molecule.

Summary

Discovering and understanding interactions between small bioactive molecules and protein receptors is fundamental to the development of novel pharmaceutical and agrochemical agents. There are many bioactive molecules for which the target receptor is unknown. Our product is a simple and highly efficient 'Magic Tag' Kit that allows immobilisation of a small bioactive molecule in a format that maximises the chances of identifying the target receptor for the bioactive molecule in a library representing the proteome of an organism of interest. The 'Magic Tag' Kit will consist of a 96 well plate, each well containing a solid support, chemically derivatised with a species that will generate a reactive intermediate capable of covalently bonding a bioactive molecule when activated. The tagged bioactive molecule will be used to isolate and identify receptors for the bioactive molecule.

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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