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BBSRC David Phillips Fellowship: The structural role of chromosomal passenger complexes involving Borealin in the maintenance of spindle integrity
Reference
BB/C520820/1
Principal Investigator / Supervisor
Dr Xuemei Yuan
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Structural Molecular Biology
Funding type
Research
Value (£)
436,434
Status
Completed
Type
Fellowships
Start date
01/10/2005
End date
30/09/2010
Duration
60 months
Abstract
The chromosomal passenger complex (Aurora B/INCENP/survivin) plays important roles in key mitotic events, including chromosome bioorientation, the spindle assembly checkpoint and cytokinesis. The newly identified chromosomal passenger protein Borealin interacts directly with survivin and INCENP in vitro and is required for chromosomal passenger complex function in kinetochore attachment error correction. The objectives of this research include structural determinations of Borealin and Borealin/survivin, Borealin/INCENP, and Borealin/survivin/-INCENP/Aurora B complexes using NMR spectroscopy, X-ray crystallography and cryo-electron microscopy.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
Structural Biology
Research Priority
X – Research Priority information not available
Research Initiative
Fellowship - David Phillips Fellowship (DF) [1995-2015]
Funding Scheme
X – not Funded via a specific Funding Scheme
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