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BBSRC David Phillips Fellowship: The role of ARAP proteins in cell motility
Reference
BB/C520712/1
Principal Investigator / Supervisor
Dr Sonja Vermeren
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Inositide
Funding type
Research
Value (£)
411,577
Status
Completed
Type
Fellowships
Start date
01/02/2006
End date
31/07/2011
Duration
66 months
Abstract
My working hypothesis is that ARAP proteins are regulating cross-talk between P13K, Rap, Rho and Arf small GTPases during cell motility. I will address this in four individual approaches: 1) Functional comparison of ARAP1, 2 and 3 using in vitro approaches and transfection-based assays. 2) Creation of ARAP3-/- keratinocyte and neutrophil model systems. 3) Analysis of ARAP3-/- keratinocytes with respects to cellular motility and adhesion. 4) Analysis of ARAP3-/- neutrophils with regards to chemotaxis, but also phagocytosis and the NADPH oxidase.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Fellowship - David Phillips Fellowship (DF) [1995-2015]
Funding Scheme
X – not Funded via a specific Funding Scheme
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