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BBSRC David Phillips Fellowship: Growth and development of bacterial 3-dimensional structures - A multidisciplinary approach

ReferenceBB/C520655/1
Principal Investigator / Supervisor Professor Jeremy Webb
Co-Investigators /
Co-Supervisors
Institution University of Southampton
DepartmentCentre for Biological Sciences
Funding typeResearch
Value (£) 406,874
StatusCompleted
TypeFellowships
Start date 01/04/2006
End date 31/03/2011
Duration60 months

Abstract

The objective of this research is to integrate approaches to the study of autonomously replicating cells in confined environments (here we consider malignancies and surface-attached bacteria). It is proposed that the evolutionary and ecological pressures for growth in these taxonomically very different systems are fundamentally the same, and thus can be addressed within the same experimental and conceptual framework. Processes of interest in tumorigenesis include i) destabilisation if the cancer cell genome, ii) viral-host cell interactions (in certain cancers) and iii) differentiation and death of cancer cells inside tumours. This project will integrate approaches to bacterial and tumour development by studying these processes in 3-dimensional structures in bacterial biofilms.

Summary

unavailable
Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsMicrobiology
Research PriorityX – Research Priority information not available
Research Initiative Fellowship - David Phillips Fellowship (DF) [1995-2015]
Funding SchemeX – not Funded via a specific Funding Scheme
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