Award details

A centre for integrative systems biology at Imperial College London (CISBIC)

Reference	BB/C519670/1
Principal Investigator / Supervisor	Professor Michael Sternberg
Co-Investigators / Co-Supervisors	Professor Mauricio Barahona, Dr Sarah Butcher, Dr Emmanuelle Caron, Professor Anthony Cass, Professor Margaret Dallman, Professor Anne Dell, Professor Kurt Drickamer, Professor Robert Endres, Professor Philippa Gardner, Professor David Holden, Professor Fotis Kafatos, Emeritus Professor Anthony Magee, Professor H Morris, Professor Stephen Muggleton, Professor Jeremy Nicholson, Professor Christopher Rawlings, Professor Sylvia Richardson, Professor Michael Stumpf, Professor Brendan Wren
Institution	Imperial College London
Department	Div of Investigative Science
Funding type	Research
Value (£)	6,473,137
Status	Completed
Type	Research Grant
Start date	01/09/2005
End date	31/08/2011
Duration	72 months

Abstract

The Centre will be located in a suite of dedicated laboratory and office facilities comprising 700 sq m of space within the recently constructed multidisciplinary Flowers Building on the South Kensington Campus, together with Core Facilities housed in adjacent buildings. The Centre will be organised on a well-established Imperial College model for inter-faculty research, with a strong management team led by international leaders in the fields of biology, mathematics and computing. The Centre will provide a comprehensive set of state-of-the-art core technologies for high-throughput genome biology and single cell imaging, with provision of robust methods for storage, management and integration of experimental data in a form suitable for use in a range of modelling approaches. The Centre will be developed around an exemplar research programme of analysis of host-pathogen interactions, focusing on basic molecular and cellular processes that will inform the management of disease in plants and animals. This will comprise a set of inter-related projects, each combining experimental and modelling components. An integrated modelling programme will focus on development of novel numerical and computational methodologies that address the challenge of integrating results obtained by application of existing modelling approaches to systems of differing biological complexity. This component of the Centre¿s activity supports research relevant to the EPSRC mission. The Centre will promote collaborative interactions amongst a broad panel of Participating Investigators and, over the five year start-up phase, will evolve into a financially self-sustaining structure. The Centre will be open to external academic and industrial collaborations and will host scientific visits by international leaders in the field of systems biology. Training in systems biology will be promoted at undergraduate and postgraduate levels, including establishment of a new MRes course which will form the basis fora 4-year PhD programme. We are requesting support of £5 million from the BBSRC and £1 million from the EPSRC. Imperial College will contribute a further £1 million in capital costs, and £5 million in recurrent costs over the next five years.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	Microbiology, Systems Biology, Technology and Methods Development
Research Priority	X – Research Priority information not available
Research Initiative	Integrative and Systems Biology (ISB) [2004-2005]
Funding Scheme	X – not Funded via a specific Funding Scheme

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