Award details

The human serum metabolome in health and disease

Reference	BB/C519011/1
Principal Investigator / Supervisor	Professor (John) Kennedy Cruickshank
Co-Investigators / Co-Supervisors	Professor Frederick Wu
Institution	The University of Manchester
Department	Medical and Human Sciences
Funding type	Research
Value (£)	230,917
Status	Completed
Type	Research Grant
Start date	01/02/2005
End date	31/01/2009
Duration	48 months

Abstract

Many arguments, including those based on metabolic Control Analysis (MCA), indicate that the metabolome should be a particularly high-resolution method for amplifying and thereby reflecting changes in the levels of gene products, especially those which accompany disease pathogenesis. A key imperative is therefore to develop and industrialise the technology optimal for determining the serum metabolome reliably, to establish the disease-independent ranges of the many hundreds of metabolites that can be observed with such technology, to recognise the disease-independent changes that occur `simply as a function of diet, gender, age, therapeutic interventions and lifestyle, and to make these data for `normals available in a web-accessible manner. Such data will form the reference baseline that will allow prognostic and diagnostic biomarkers for disease progression to be identified reliably; this will show the high- resolution discrimination possible with metabolomic data for both diagnosis and treatment. In parallel, we shall contribute to the development of (i) robust data models for metabolome data, and (ii) machine learning methods of classification in which the `gold standard diagnosis may be imperfectly reliable. The deliverables will be both underpinning knowledge of the human serum metabolome (probably including the discovery of many novel metabolites) and the identification of candidate biomarkers for two diseases.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	Pharmaceuticals, Technology and Methods Development
Research Priority	X – Research Priority information not available
Research Initiative	LINK: Applied Genomics (APG) [2000-2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BB/C519003/1 The human serum metabolome in health and disease

BB/C51902X/1 The human serum metabolome in health and disease

BB/C519038/1 The human serum metabolome in health and disease

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