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Award details
A genomic and genetic analysis of Notch signalling as a modulator of the immune response
Reference
BB/C51889X/1
Principal Investigator / Supervisor
Dr Martin Turner
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
330,886
Status
Completed
Type
Research Grant
Start date
08/03/2005
End date
07/03/2008
Duration
36 months
Abstract
The proposed division of roles within this research plan is therefore as follows: Lorantis will produce research-level quantities of the recombinant Notch ligands Delta-3, -4 and Jagged-1 and -2 and will generate additional microarray data sets using these ligands. Lorantis will use its RNAi expertise to generate siRNA sequences for novel gene sequences identified by these screens. siRNAs and cDNAs for novel genes will be passed to the Turner group by Lorantis for retroviral transduction of primary cells and subsequent functional analysis. Gene targeting expertise for those genes deemed suitably interesting will be provided by the Turner laboratory.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
LINK: Applied Genomics (APG) [2000-2004]
Funding Scheme
X – not Funded via a specific Funding Scheme
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