Award details

Canine population genetics and study design for linkage disequilibrium gene mapping

Reference	BB/C518865/1
Principal Investigator / Supervisor	Professor David Balding
Co-Investigators / Co-Supervisors
Institution	Imperial College London
Department	School of Public Health
Funding type	Research
Value (£)	204,678
Status	Completed
Type	Research Grant
Start date	03/01/2005
End date	02/07/2008
Duration	42 months

Abstract

We will: (i) develop computer simulation models of the population genetics of several dog breeds, informed by Kennel Club records; (ii) calibrate the models using genotypes (assayed by MF) of small random samples from the breeds, at several genomic locations and various marker spacings; (iii) use the models to seek optimal designs for association studies at both the candidate-gene and the whole-genome scales; (iv) sample cases and controls for several breed-disease combinations; (v) perform association studies according to the recommended designs. It is possible that linkage disequilibrium (LD) in some breeds will turn out to be extensive enough, and genotyping costs fall sufficiently rapidly, that genome-wide LD scans can be performed within the timeframe of the present project. If not, we will at a minimum investigate a large number of candidate genes, and conduct pilot studies at the whole chromosome level. The results of the present study may lead to diagnostic genetic tests, but perhaps more importantly they will permit future whole-genome LD studies to be well-designed, and have well-characterised prospects of success. The many similarities between human and canine disease mean that the results from studies in dogs are likely to be of great benefit to researchers seeking genetic contributions to the human forms of these diseases.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	LINK: Applied Genomics (APG) [2000-2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

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