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Can very early changes in mitochondrial DNA alter future health?

Reference	BB/C518273/1
Principal Investigator / Supervisor	Dr Josie McConnell
Co-Investigators / Co-Supervisors	Professor John Clark, Professor Simon Heales, Dr Ian Holt, Professor Martin Johnson, Professor Susan Ozanne, Dr Susan Jane Pickering, Professor Lucilla Poston, Dr Jeremy Neil Skepper
Institution	King's College London
Department	Obstetrics & Gynaecology
Funding type	Research
Value (£)	253,389
Status	Completed
Type	Research Grant
Start date	01/09/2005
End date	30/11/2008
Duration	39 months

Abstract

We have recently discovered a window of mitochondrial DNA replication immediately after fertilisation in preimplantation mouse embryos. Environmental factors can influence replication during this period and once altered the mtDNA remains reset during fetal and post natal life. We propose to precisely change mtDNA of the preimplantation embryo in vitro and to determine the long term consequences of these changes by replacing embryos with altered mitochondrial genome into foster mothers and analysing the physiology of the offspring. We also plan to define the duration of this period of turnover in human embryos and determine the effects of culture on human embryonic mitochondrial DNA.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Ageing
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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