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Investigation of the role of Jumonji domains in chromatin remodelling

Reference	BB/C518230/1
Principal Investigator / Supervisor	Professor Aidan Doherty
Co-Investigators / Co-Supervisors	Dr Robert Pitcher
Institution	University of Sussex
Department	Genome and Damage Stability Centre
Funding type	Research
Value (£)	199,720
Status	Completed
Type	Research Grant
Start date	01/07/2005
End date	30/09/2008
Duration	39 months

Abstract

Genomic DNA is packaged in the cell nucleus as a protein complex with histones to form a higher ordered structure known as chromatin. Changes in the chromatin structure play a key role in the regulation of the mammalian DNA, controlling many cellular processes including transcription, replication and repair. Eukaryotic chromatin is regulated by a number of modification enzymes including histone methylases, phosphorylases and acetylases. Little is known about whether or not such modifications occur in prokaryotes. We are interested in understanding more about the enzymes that regulate bacterial chromatin. We have recently discovered two bacterial proteins that resemble eukaryotic histone modification enzymes. The major aim of this proposal is to establish whether these bacterial enzymes modify bacterial chromatin to regulate the dynamics of DNA structure, and if so, what does it also tell us about the function of these proteins in the eukarya.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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