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Translation control of pro-apoptotic genes during the induction of apoptosis

Reference	BB/C516095/1
Principal Investigator / Supervisor	Professor Martin Bushell
Co-Investigators / Co-Supervisors	Professor Anne Willis
Institution	University of Nottingham
Department	Sch of Pharmacy
Funding type	Research
Value (£)	198,467
Status	Completed
Type	Research Grant
Start date	01/03/2005
End date	30/04/2008
Duration	38 months

Abstract

Apoptosis is an important physiological process by which cell and tissue growth, differentiation and programmes of development are regulated [1]. During the induction of apoptosis there are extensive changes to the translational apparatus and these result in a 90 per cent reduction in protein synthesis [2-10]. Using cDNA micro-array technology we have found that there are dramatic changes in the identity of mRNA species translated during the induction of apoptosis. Interestingly, a number of the genes that are selected for translation play major roles in the apoptotic process, including caspase-3, apoptosis-inducing factor and a novel protein that has high homology to endonuclease G. This proposal aims to investigate (1) the function and role of the novel endonuclease during the induction of apoptosis; (2) how these mRNAs are selected for translation during the induction of apoptosis; (3) whether there are sequence motifs and/or structural elements within the mRNAs of these pro-apoptotic genes that allow coordinate regulation of gene expression during apoptosis.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	Ageing
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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