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Defining the function and regulation of the SCF complex involved in sugar mediated growth control in Arabidopsis

Reference	BB/C515620/1
Principal Investigator / Supervisor	Professor Michael Bevan
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	Cell and Develop Biology
Funding type	Research
Value (£)	229,000
Status	Completed
Type	Research Grant
Start date	28/11/2005
End date	27/11/2008
Duration	36 months

Abstract

We propose to define the function of a novel F box protein in sugar- mediat3ed growth responses in Arabidopsis. This protein, encoded by the High sugar Response 5 (HSR5) gene, was identified in a screen for Arabidopsis mutants exhibiting elevated expression of sugar- regulated genes and sugar- hypersensitive growth responses. We have established that HSR5 interacts with ASK proteins, which are subunits of the SCF complex that targets proteins for ubiquitination and proteasome- mediated degradation. We will establish if the activity of this SCFHSR5 complex is regulated by glucose and two regulatory proteins previously implicated in sugar responses. We will also identify proteins that may be potential targets for HSR5- mediated degradation and establish their function, in order to establish the cellular processes that may be affected by the SCFHSR5 complex. These analyses will define an important sugar-controlled regulatory network and may also reveal, through a wider definition of the specificity and regulation of proteolysis, a regulatory network involving light, hormones and sugars that integrates growth and development.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	Plant Science
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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