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Regulation of the Brn-3a transcription factor by phosphorylation

Reference	BB/C513018/1
Principal Investigator / Supervisor	Professor David Latchman
Co-Investigators / Co-Supervisors
Institution	University College London
Department	Institute of Child Health
Funding type	Research
Value (£)	189,521
Status	Completed
Type	Research Grant
Start date	01/10/2005
End date	30/11/2008
Duration	38 months

Abstract

The Bm-3a transcription factor plays a key role in promoting neuronal differentiation and protecting neuronal cells from apoptosis. We have recently demonstrated, for the first time, that Bm-3a can be modified by phosphorylation and that such phosphorylation is enhanced during neuronal differentiation. Moreover, mutation of two adjacent, potentially phosphorylatable, serine residues in Bm-3a blocks its ability to induce neuronal differentiation. In this project we will determine whether one or both of these serine residues is critical for this effect of phosphorylation and will then elucidate the role of phosphorylation in the differentiation-inducing and anti-apoptotic effects of BM-3a using both in vitro and in vivo approaches. In addition, we will examine the signalling pathways involved in the phosphorylation of Bm-3a and the mechanisms by which such phosphorylation affects its functional activity.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	Ageing, Neuroscience and Behaviour
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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