Award details

Role of the TCP1 in calcium entry into the body

Reference	BB/C51300X/1
Principal Investigator / Supervisor	Professor George Kellett
Co-Investigators / Co-Supervisors	Miss Emma Morgan, Professor Dale Sanders
Institution	University of York
Department	Biology
Funding type	Research
Value (£)	210,283
Status	Completed
Type	Research Grant
Start date	01/01/2005
End date	31/12/2007
Duration	36 months

Abstract

The entry of dietary calcium into the body through the apical membrane of the small intestine is a major determinant of the calcium concentration in the extracellular fluid, which is under very tight control through the additional processed of bone adsorption resorption and kidney resorption. We have discovered that the apical membrane of rodent small intestine contains the novel two pore calcium channel, TPC1, which therefore most likely plays a role in calcium entry. However, the properties of TPC1 are unknown. The purpose of this project is therefore to determine the functional role of TPC1 in calcium entry. To this end, mouse TPC1 will be expressed in oocytes, yeast mutant or HEK293 cells in order to determine its cation specificity, its electrophysiological properties, whether it is voltage-gated and its pharmacological profile. Equipped with a knowledge of these properties, we will investigate the regulation of TPC1 by PTH, vitamin D and dietary calcium in different regions of the mouse intestine.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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