Award details

Multi-photon microscopy for functional imaging of mammalian excitable cells.

Reference	BB/C511464/1
Principal Investigator / Supervisor	Professor Ole Paulsen
Co-Investigators / Co-Supervisors	Dr Peter Kohl, Professor David Paterson, Dr Ian Thompson
Institution	University of Oxford
Department	Physiology Anatomy and Genetics
Funding type	Research
Value (£)	199,513
Status	Completed
Type	Research Grant
Start date	01/12/2004
End date	30/11/2005
Duration	12 months

Abstract

Four principal investigators (PIs) in our Department have set up a consortium to advance functional imaging of excitable cells, including sub-cellular, cellular, culture, and tissue levels. Due to the unprecedented spatial and temporal resolution of multi-photon imaging, these techniques have become indispensable tools in this research. All PIs are already involved, either directly or via collaboration, in studies using confocal and multiphoton microscopy. They have obtained crucial expertise, published or submitted independent work, and gathered pilot data for future projects. We have reached a level now where more significant progress is hindered by the lack of access to multiphoton microscopy in our Department. Given our experience and research plans, we are in a good position to bid for a multi-photon microscope. The long-term research plans of all PIs focus on excitable cell physiology, in particular cardiac myocytes and central neurons, which conform to strategic target areas for this department. While PIs will enjoy priority booking-rights, other members of this department will be given access to the facility for pilot studies and small projects, subject to approval by the board. The group of PIs has already successful experience in managing an old multiuser confocal microscope, which was used for simple fluorescence immunolabelling.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Research Equipment Initiative 2004 (RE4) [2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

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