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Solid state NMR strutural investigtions of biomembranes - structure and function of membrane peptides proteins and drug-target recognition

Reference	BB/C510924/1
Principal Investigator / Supervisor	Dr Boyan Bonev
Co-Investigators / Co-Supervisors
Institution	University of Nottingham
Department	Sch of Biomedical Sciences
Funding type	Research
Value (£)	199,982
Status	Completed
Type	Research Grant
Start date	01/12/2004
End date	30/11/2005
Duration	12 months

Abstract

The postgenomic era calls for the development and application of novel technologies for structural analysis of macromolecules. The principal objective of this proposal is the introduction of solid state NMR, a novel method for structural studies of biomembrane systems, to the rapidly growing research community at the School of Biomedical Sciences and the new Centre for Biomolecular Sciences at the University of Nottingham. Solid state NMR is a new and powerful method for quantitative analysis of intermolecular interactions and elucidation of molecular structures within the native environment of biological membranes. The requested instrument will aid the interdisciplinary interplay between biology, physics and chemistry with applications to pharmacology at Nottingham. The addition of solid state NMR to the more conventional methodology already in place at the School and in Nottingham will affirm the commitment of the University of Nottingham to postgenomic technologies and to structural biology. The instrument will also help the development of new structural methods and will provide base for training of staff and students in biophysics and biochemistry of biomembranes and biopolymers. Obtaining structural details from membrane proteins is crucial to rational drug design. Approximately 30 per cent of the human genome encodes membrane proteins and estimated 60 per cent of all targets, used at present for drug design by the pharmaceutical industry, are membrane proteins. However, structures of membrane proteins and peptides have been notoriously difficult to resolve and of all known protein structures only 1 in a 1000 is of a membrane protein. Solid state NMR is a particularly successful technique for obtaining structural information from membrane proteins at atomic resolution, which continue to elude analysis by crystallography and solution NMR. Here we propose to apply solid state NMR to studies of drug-target interactions in biomembranes, the responses of membranesto drug and toxin attack, the structure of membrane-associated and integral membrane proteins and peptides and to structural studies of biopolymers.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Research Equipment Initiative 2004 (RE4) [2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

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