Award details

Realising the potential of glycoprotein processing enzymes.

Reference	BB/C510824/1
Principal Investigator / Supervisor	Professor Benjamin Davis
Co-Investigators / Co-Supervisors	Professor Harry Gilbert
Institution	University of Oxford
Department	Oxford Chemistry
Funding type	Research
Value (£)	99,978
Status	Completed
Type	Research Grant
Start date	15/11/2004
End date	14/05/2006
Duration	18 months

Abstract

An ever-growing majority of protein therapeutics are glycosylated proteins. However, all current methods used for their large-scale production create mixtures of different carbohydrate patterns in these proteins. There is a pressing need for methods that create pure carbohydrate forms to allow truly accurate assessment of the effects of protein structure on biological activity and to ensure that contamination by potentially toxic forms can be avoided. The enzymes that are the focus of this application are rare examples of powerful catalysts for the selective introduction of carbohydrates onto protein surfaces. They therefore represent powerful untapped synthetic tools for use in the construction of pure glycoprotein forms of high potential value. Based on initial promising indications of activity, this proposal will assess the breadth of utility of these enzymes when used in conjunction with IP-protected protein glycosylation methods with a view to full exemplification and exploitation.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Follow-On Fund (FOF) [2004-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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