Award details

The role of cyclin dependent protein kinase A in translational control of gene expression in Arabidopsis.

Reference	BB/C507988/1
Principal Investigator / Supervisor	Professor John Doonan
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	Cell and Develop Biology
Funding type	Research
Value (£)	231,693
Status	Completed
Type	Research Grant
Start date	16/03/2005
End date	15/03/2008
Duration	36 months

Abstract

Cell division and cell growth are tightly coupled but the mechanisms are unknown. We have isolated a novel Cyclin Dependent protein Kinase (CDK) complex containing the translational initiation factor, eIF4A specifically from proliferating Arabidopsis suspension cells but this complex is not found in growing post-proliferative cells. This inspection points to a molecular mechanism linking cell proliferation and growth with the control of translational control. The aim of this project is to characterise eIF4A containing protein complexes during different growth phases and study their effect on translation with a view to understanding their function in cell proliferation and growth.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search