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Elucidation of the role of kainate receptors in hippocampal synaptic mechanisms using novel pharmacological tools

Reference	BB/C507045/1
Principal Investigator / Supervisor	Professor David Jane
Co-Investigators / Co-Supervisors	Professor Graham Collingridge, Professor Jeremy Henley
Institution	University of Bristol
Department	Physiology and Pharmacology
Funding type	Research
Value (£)	371,997
Status	Completed
Type	Research Grant
Start date	01/10/2004
End date	31/12/2007
Duration	39 months

Abstract

The lack of subtype selective kainate receptor antagonists is the principal impediment to the elucidation of the physiological roles of native kainate receptor subtypes in the central nervous system. We plan to adopt an integrated multidisciplinary approach involving synthetic organic chemistry, computer aided drug design, molecular biology and electrophysiology to efficiently identify novel pharmacological tools to characterise the physiological roles of kainate receptor subtypes. In particular, we will develop potent and selective antagonists for GluR5 and GluR6 receptors based on leads we have already identified so that the role of these receptors in hippocampal synaptic transmission and synaptic plasticity can be established.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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