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How does serrate control arabidopsis shoot development?
Reference
BB/C506348/1
Principal Investigator / Supervisor
Professor Miltos Tsiantis
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Plant Sciences
Funding type
Research
Value (£)
240,244
Status
Completed
Type
Research Grant
Start date
01/01/2005
End date
31/07/2008
Duration
43 months
Abstract
We will investigate how SERRATE (SE) regulates Arabidopsis shoot development. Shoot development depends upon the continual recruitment of lateral organs from the shoot apical meristem and the replenishment of this cell population. Leaf founder cell recruitment requires the down-regulation of KNOX (KNOTTED 1 like homeobox) expression and subsequent leaf development requires the acquisition of adaxial-abaxial polarity. We have shown that SE controls expression of HD-ZIPIII (homeodomain leucine zipper class three) genes that specify adaxial identity in Arabidopsis leaves. We have also shown that SE controls target genes of KNOX transcription factors that are known to control meristem development. We propose to use molecular genetics to understand the precise contributions of HD-ZIPIII genes and KNOX target genes to SE function. We will also investigate the mechanism by which SE regulates HD-ZIPIII genes. Specifically, we will investigate the hypothesis that SE acts via an endogenous post-transcriptional gene silencing process.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
Plant Science
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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