Award details

Regulation of synaptic efficacy and behaviour by ephrin-B2

Reference	BB/C505816/1
Principal Investigator / Supervisor	Dr Isabella Gavazzi
Co-Investigators / Co-Supervisors	Professor John Wood
Institution	King's College London
Department	Wolfson Centre for Age Related Diseases
Funding type	Research
Value (£)	140,103
Status	Completed
Type	Research Grant
Start date	28/02/2005
End date	27/06/2008
Duration	40 months

Abstract

A role for Eph-ephrinB2 interactions as modulators of synaptic efficacy in the spinal cord has been proposed. Dimeric ephrinB2-Fc fusion molecules activate Eph tyrosine kinase receptors causing NMDA receptor phosphorylation and lowered pain thresholds in rats. Conversely, inflammatory stimuli that normally cause hyperalgesia fail to do so when ephrin scavenging Eph-receptor-bodies are applied to the spinal cord. Here, we outline how tissue-specific gene ablation techniques that abolish ephrinB2 expression selectively in damage sensing sensory neurons, will allow us to examine the effects of ephrinB2 on dorsal horn synaptic efficacy and behaviour in detail, using the electrophysiological, biochemical and behavioural studies.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Neuroscience and Behaviour
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BB/C505775/1 Regulation of synaptic efficacy and behaviour by ephrin-B2

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search