Award details

Regulation of synaptic efficacy and behaviour by ephrin-B2

Reference	BB/C505775/1
Principal Investigator / Supervisor	Professor John Wood
Co-Investigators / Co-Supervisors	Dr Isabella Gavazzi
Institution	University College London
Department	Genetics Evolution and Environment
Funding type	Research
Value (£)	224,172
Status	Completed
Type	Research Grant
Start date	01/04/2005
End date	31/03/2008
Duration	36 months

Abstract

A role for Eph-ephrinB2 interactions as modulators of synaptic efficacy in the spinal cord has been proposed. Dimeric ephrinB2-Fc fusion molecules activate Eph tyrosine kinase receptors causing NMDA receptor phosphorylation and lowered pain thresholds in rats. Conversely, inflammatory stimuli that normally cause hyperalgesia fail to do so when ephrin scavenging Eph-receptor-bodies are applied to the spinal cord. Here, we outline how tissue-specific gene ablation techniques that abolish ephrinB2 expression selectively in damage sensing sensory neurons, will allow us to examine the effects of ephrinB2 on dorsal horn synaptic efficacy and behaviour in detail, using electrophysiological, biochemical and behavioural studies.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BB/C505816/1 Regulation of synaptic efficacy and behaviour by ephrin-B2

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