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Structure and function of succinate dehydrogenase
Reference
BB/C505116/1
Principal Investigator / Supervisor
Professor So Iwata
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
209,327
Status
Completed
Type
Research Grant
Start date
01/10/2004
End date
30/06/2008
Duration
45 months
Abstract
We have recently revealed the structure of succinate dehydrogenase (complex II; or succinate: ubiquinone oxidoreductase, SQR) at 2.6 Angstrom. SQR is a functional member of both the Krebs cycle and the aerobic respiratory chain, thus an essential enzyme for any organisms, which perform oxygen respiration. Mutations of SQR cause tumours for human, premature aging for Caenorhabditis elegans and fungicide resistance for fungal pathogens. This proposal is to study the structures and functions of these mutants of mitochondrial SQRs using E. coli SQR system. E. coli SQR is an ideal model system to study these mutants since we can produce them in large quantity, which is essential for the biochemical and crystallographic studies. This proposal could reveal molecular mechanisms of these genetic disorders in human and the nematode and of fungicide resistance in fungal pathogens.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
Ageing, Microbiology, Structural Biology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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