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Combinatorial bioformulation of epidermal growth factors

Reference	BB/C50466X/1
Principal Investigator / Supervisor	Dr Ana Maria Gonzalez
Co-Investigators / Co-Supervisors	Professor Andrew Baird, Professor Martin Berry, Professor Margaret Lawrence, Professor Ann Logan
Institution	University of Birmingham
Department	Medical Sciences - Medicine
Funding type	Research
Value (£)	217,842
Status	Completed
Type	Research Grant
Start date	01/01/2005
End date	31/08/2008
Duration	44 months

Abstract

Biopharmaceutical drug development is hampered by an inability to formulate proteins to enter the brain. Unlike small molecule drugs, biopharmaceuticals (e.g. antibodies, peptides and proteins) cannot be modified by rational design without having a profound - and often unexpected - effects on their biological activity. A multidisciplinary group of 5 co-applicants will apply a technique called Combinatorial Bioformulation to (1) identify peptide-chimera or epidermal growth factor (EGF) that translocate from blood into the CNS, (2) characterise their effects on CNS function and (3) establish a structural basis for their activity because EGF can stimulate stem cells, glia and neurons but only when it is introduced directly into the CNS.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	Neuroscience and Behaviour, Pharmaceuticals
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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