Award details

Biosynthesis of complex multi-subunit membrane proteins

Reference	BB/C006844/2
Principal Investigator / Supervisor	Professor Frank Sargent
Co-Investigators / Co-Supervisors
Institution	University of Dundee
Department	College of Life Sciences
Funding type	Research
Value (£)	53,779
Status	Completed
Type	Research Grant
Start date	01/07/2007
End date	31/03/2008
Duration	9 months

Abstract

The Tat protein transport system is a remarkable molecular machine dedicated to the transport of fully folded proteins across energy-transducing membranes. In an exciting new development we have established that up to one fifth of all traffic on the Escherichia coli Tat pathway are integral membrane proteins. One of the main integral membrane proteins assembled by the Tat pathway is the nitrate- inducible formate dehydrogenase. Assembly and integration mechanisms for this multi-subunit respiratory enzyme are so efficient that it can account for a very high proportion of total membrane protein. This project aims to determine the mechanism of Tat-dependent membrane protein targeting and integration into the lipid bilayer. We will also address the wider cellular processes governing assembly of the mechanism of Tat-dependent membrane protein formate dehydrogenase. Tat-dependent integral membrane proteins are present in a whole spectrum of biological systems therefore studies of the model prokaryote E. coli would set a paradigm in the field.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BB/C006844/1 Biosynthesis of complex multi-subunit membrane proteins

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