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The role of the Arabidopsis Sumo-Protease STR1 in salt stress signalling.

Reference	BB/C006488/1
Principal Investigator / Supervisor	Professor Ari Sadanandom
Co-Investigators / Co-Supervisors	Dr Peter Dominy
Institution	University of Glasgow
Department	School of Life Sciences
Funding type	Research
Value (£)	325,875
Status	Completed
Type	Research Grant
Start date	25/07/2005
End date	24/07/2008
Duration	36 months

Abstract

Developing crops that can yield well in saline soils is a major objective in the twenty first century. In order to produce salt tolerant crops it is crucial to understand the key molecular mechanisms enabling plants to perceive and trigger signalling cascades which allows them to respond to salt stress. In recent years SUMO modification of regulatory proteins is emerging as an important mechanism controlling cellular signalling pathways in yeast and mammals. SUMO-proteases have been implicated as critical players during SUMO-mediated signalling. Our preliminary work has identified a SUMO-protease, STR1 that is vital for salt tolerance in Arabidopsis. This project details a thorough characterisation of the novel SUMO-protease thereby enabling us to dissect the molecular and biochemical role of SUMOylation in mediating whole plant and cellular signalling during salt stress. Tissue and cellular localisation of the site of action of STR1-dependent signalling will be determined. Furthermore the study has the potential to reveal the identity of conserved SUMOlated regulators of salt tolerance mechanisms in plants. Such knowledge will open new areas of research into stress signalling in plants.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	Plant Science
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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